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个人简历
个人介绍文字
杜鹏，北京大学生命科学学院/北大-清华生命联合中心研究员、博雅特聘教授。2012年于北京大学获得博士学位，后进入哈佛大学医学院/波士顿儿童医院从事博士后研究。2018年起任北京大学生命科学学院/北大-清华生命科学联合中心研究员。其课题组主要从事干细胞和转化医学中RNA生物学相关研究，同时致力于在动物细胞中重组植物或微生物中特异的RNA调控通路，并研究其潜在的转化医学的应用价值。以独立及共同通讯作者，分别在Cell, Nature，Cell Stem Cell等杂志上发表多篇论文。并获得国家杰出青年科学基金，海外高层次人才项目（青年），基金委原创探索计划项目，科技部国家重点研发计划及颠覆性技术创新项目的支持和资助；
教育经历
2006.09-2012.07 博士，北京大学生命科学学院；
2002.09-2006.07 学士，山东师范大学生命科学学院
2002.09-2006.07 学士，山东师范大学生命科学学院
工作经历
2018.09-至今 助理教授/副教授/教授 北京大学生命科学学院/北大-清华生命科学联合中心；
2018.09-至今 研究员 北京大学生命科学学院/北大-清华生命科学联合中心；
2012.09-2018.09 博士后 哈佛大学医学院/波士顿儿童医院；
2010.09-2012.04 访问学者 加州大学河滨分校
2018.09-至今 研究员 北京大学生命科学学院/北大-清华生命科学联合中心；
2012.09-2018.09 博士后 哈佛大学医学院/波士顿儿童医院；
2010.09-2012.04 访问学者 加州大学河滨分校
荣誉奖励
中国细胞生物学学会青年科学家奖, 2024
亚洲青年科学家奖，2023
钟南山青年科技奖，2023
中源协和生命医学创新突破奖，2022
顾孝诚讲座奖，2022
优秀论文指导教师奖，2022
中国干细胞生物学学会卓越青年研究员奖，2021
勃林格殷格翰青年研究员奖，2021
东宝奖教金，2021;
拜耳学者奖, 2019;
億方学者, 2019;
哈佛华人生命科学研究奖，2016；
北京大学优秀毕业论文奖，2012
亚洲青年科学家奖，2023
钟南山青年科技奖，2023
中源协和生命医学创新突破奖，2022
顾孝诚讲座奖，2022
优秀论文指导教师奖，2022
中国干细胞生物学学会卓越青年研究员奖，2021
勃林格殷格翰青年研究员奖，2021
东宝奖教金，2021;
拜耳学者奖, 2019;
億方学者, 2019;
哈佛华人生命科学研究奖，2016；
北京大学优秀毕业论文奖，2012
学术任职
2023年-至今，中国细胞生物学会发育生物学分会副会长
2023年-至今，中国细胞生物学会干细胞生物学分会委员
2023年-至今，北京细胞生物学会委员
2022年-至今，北京大学教育部细胞增殖与分化重点实验室副主任
2023年-至今，中国细胞生物学会干细胞生物学分会委员
2023年-至今，北京细胞生物学会委员
2022年-至今，北京大学教育部细胞增殖与分化重点实验室副主任
杂志任职
2023年-至今，青年编委，中国科学：生命科学（SCLS）
科研领域描述
本课题组的研究集中在RNA生物学与干细胞生物学。我们综合运用传统的生物化学，分子生物学，结合高通量测序，基因组学，生物信息学等手段来分析和鉴定未知的RNA调控通路，研究相关RNA调控通路在胚胎干细胞的分化命运决定和早期胚胎发育中的功能。同时，我们致力于在动物细胞中重组植物或微生物中特异的RNA调控通路，并分析其潜在的对于基础科学研究和转化医学研究中的价值。
主要研究课题：
1, 鉴定未知的RNA调控元件及分析其对应的调控机制。
2, 研究RNA调控如何决定胚胎干细胞全能性及多能性状态的转化及分化命运。
3, 哺乳动物细胞中植物或微生物RNA调控通路的重建及其潜在应用。
主要研究课题：
1, 鉴定未知的RNA调控元件及分析其对应的调控机制。
2, 研究RNA调控如何决定胚胎干细胞全能性及多能性状态的转化及分化命运。
3, 哺乳动物细胞中植物或微生物RNA调控通路的重建及其潜在应用。
代表性论文
1. Shiyu Li, Min Yang, Hui Shen, Li Ding, Xuehui Lyu, Kexin Lin, Jennie Ong, and Peng Du*. Capturing totipotency in human cells through spliceosomal repression. Cell,2024; https://doi.org/10.1016/j.cell.2024.05.010.
2. Peng Du* and Jun Wu*. Hallmarks of totipotent and pluripotent stem cell states. Cell Stem Cell, 2024; 31:312-333. (Review)
3. Min Yang, Jennie Ong, Fanju Meng, Feixiang Zhang, Hui Shen, Kerstin Kitt, Tengfei Liu, Wei Tao and Peng Du*. Spatiotemporal insight of early pregnancy governed by immune-featured stromal cells. Cell, 2023; 186:4271-4288.
4. Yanxin Li, Zhongqiu Li, Changliang Wang, Min Yang, Ziqing He, Feiyang Wang, Yuehong Zhang, Rong Li, Yunxia Gong, Binhong Wang, Baoguang Fan, Chunyue Wang, Lei Chen, Hong Li, Peifu Shi, Nana Wang, Zhifeng Wei, Yan-Ling Wang, Lei Jin*, Peng Du*, Ji Dong*, and Jianwei Jiao*. Spatiotemporal transcriptome atlas reveals the regional specification of the developing human brain. Cell, 2023; 186:5892-5909.
5. Jianfeng Fu, Siru Zhou, Huilin Xu, Liming Liao, Hui Shen, Peng Du, and Xiaofeng Zheng*. ATM–ESCO2–SMC3 axis promotes 53BP1 recruitment in response to DNA damage and safeguards genome integrity by stabilizing cohesin complex. Nucleic acids research, 2023; 51:7376-7391.
6. Yingzi Cui, Ye Qi, Li Ding, Shuangjin Ding, Zonglin Han, Yangming Wang* and Peng Du*. miRNA dosage control in development and human disease. Trends in Cell Biology, 2023; DOI: https://doi.org/10.1016/j.tcb.2023.05.009. (Review)
7. Ye Qi, Li Ding, Siwen Zhang, Shengze Yao, Jennie Ong, Yi Li, Hong Wu, and Peng Du* . A plant immune protein enables broad antitumor response by rescuing microRNA deficiency in cancers. Cell, 2022; 185:1888-1904.
8. Yanxin Li, Zhongqiu Li, Min Yang, Feiyang Wang, Yuehong Zhang, Rong Li, Qian Li, Yunxia Gong, Binhong Wang, Baoguang Fan, Chunyue Wang, Lei Chen, Hong Li, Jennie Ong, Zhaoqian Teng, Lei Jin*, Yan-Ling Wang*, Peng Du* and Jianwei Jiao*. Decoding the temporal and regional specification of microglia in the developing human brain. Cell Stem Cell, 2022; 29: 620-634.
9. Hui Shen, Min Yang, Shiyu Li, Jing Zhang, Bing Peng, Chunhui Wang, Zai Chang, Jennie Ong, and Peng Du*. Mouse totipotent stem cells captured and maintained through spliceosomal repression. Cell, 2021. 184:2843-2859.
10. Yingzi Cui, Xuehui Lyu, Li Ding, Lan Ke, Dechang Yang, Mehdi Pirouz, Ye Qi, Jennie Ong, Ge Gao, Peng Du*, and Richard Gregory*. Global miRNA dosage control of embryonic germ layer specification. Nature 2021; 593:602-606.
11. Bingqing Xie, Da Sun, Yuanyuan Du, Jun Jia, Shicheng Sun, Jun Xu, Yifang Liu, Chengang Xiang, Sitong Chen, Huangfan Xie, Qiming Wang, Guangya Li, Xuehui Lyu, Hui Shen, Shiyu Li, Min Wu, Xiaonan Zhang, Yue Pu, Kuanhui Xiang, Weifeng Lai, Peng Du, Zhenghong Yuan, Cheng Li, Yan Shi, Shichun Lu, Hongkui Deng. A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts. Cell research 2019; 29: 696-710.
a) 实验室成立前：
12. Junho Choe, Shuibin Lin, Wencai Zhang, Qi Liu, Longfei Wang, Julia Ramirez-Moya, Peng Du, Wantae Kim, Shaojun Tang, Piotr Sliz, Pilar Santisteban, Rani E George, William G Richards, Kwok-Kin Wong, Nicolas Locker, Frank J Slack, Richard I Gregory. mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis. Nature， 2018; 561:556-560.
13. Hee Ho Park, Robinson Triboulet, Martin Bentler, Swaroopa Guda, Peng Du, Haiming Xu, Richard I Gregory, Christian Brendel, David A Williams. Drosha knockout leads to enhancement of viral titers for vectors encoding miRNA-adapted shRNAs. Molecular Therapy, 2018; 12:591-599.
14. Peng Du, Mehdi Pirouz, Jiho Choi, Aaron J Huebner, Kendell Clement, Alexander Meissner, Konrad Hochedlinger, Richard I Gregory. An intermediate pluripotent state controlled by microRNAs is required for the naive-to-primed stem cell transition. Cell Stem Cell, 2018; 22:851-864.
15. Mehdi Pirouz, Peng Du, Marzia Munafò, Richard I Gregory. Dis3l2-mediated decay is a quality control pathway for noncoding RNAs. Cell Reports, 2016; 16:1861-73.
16. Shuibin Lin, Junho Choe, Peng Du, Robinson Triboulet, Richard I Gregory. METTL3 promotes translation in human cancer cells. Molecular Cell, 2016; 62:335-45.
17. Peng Du, Longfei Wang, Piotr Sliz, Richard I Gregory. A biogenesis step upstream of microprocessor controls miR-17∼92 expression. Cell 2015; 162:885-99.
18. Swaroopa Guda, Christian Brendel, Raffaele Renella, Peng Du, Daniel E Bauer, Matthew C Canver, Jennifer K Grenier, Andrew W Grimson, Sophia C Kamran, James Thornton, Helen de Boer, David E Root, Michael D Milsom, Stuart H Orkin, Richard I Gregory, David A Williams. miRNA-embedded shRNAs for lineage-specific BCL11A knockdown and hemoglobin F induction. Molecular Therapy, 2015; 10.1038.
19. James E Thornton, Peng Du, Lili Jing, Ljiljana Sjekloca, Shuibin Lin, Elena Grossi, Piotr Sliz, Leonard I Zon, Richard I Gregory. Selective microRNA uridylation by Zcchc6 (TUT7) and Zcchc11 (TUT4). Nucleic Acids Res, 2014; 42:11777-91.
20. Mengji Cao#, Peng Du#, Xianbing Wang, Yun-Qi Yu, Yan-Hong Qiu, Wanxiang Li, Amit Gal-On, Changyong Zhou, Yi Li, Shou-Wei Ding. Virus infection triggers widespread silencing of host genes by a distinct class of endogenous siRNAs in Arabidopsis. PNAS, 2014; 111:14613-8.
21. Peng Du#, Jianguo Wu#, Jiayao Zhang, Shuqi Zhao, Hong Zheng, Ge Gao, Liping Wei, Yi Li. Viral infection induces expression of novel phased microRNAs from conserved cellular microRNA precursors. PLoS Pathogens, 2011; 7:e1002176.
2. Peng Du* and Jun Wu*. Hallmarks of totipotent and pluripotent stem cell states. Cell Stem Cell, 2024; 31:312-333. (Review)
3. Min Yang, Jennie Ong, Fanju Meng, Feixiang Zhang, Hui Shen, Kerstin Kitt, Tengfei Liu, Wei Tao and Peng Du*. Spatiotemporal insight of early pregnancy governed by immune-featured stromal cells. Cell, 2023; 186:4271-4288.
4. Yanxin Li, Zhongqiu Li, Changliang Wang, Min Yang, Ziqing He, Feiyang Wang, Yuehong Zhang, Rong Li, Yunxia Gong, Binhong Wang, Baoguang Fan, Chunyue Wang, Lei Chen, Hong Li, Peifu Shi, Nana Wang, Zhifeng Wei, Yan-Ling Wang, Lei Jin*, Peng Du*, Ji Dong*, and Jianwei Jiao*. Spatiotemporal transcriptome atlas reveals the regional specification of the developing human brain. Cell, 2023; 186:5892-5909.
5. Jianfeng Fu, Siru Zhou, Huilin Xu, Liming Liao, Hui Shen, Peng Du, and Xiaofeng Zheng*. ATM–ESCO2–SMC3 axis promotes 53BP1 recruitment in response to DNA damage and safeguards genome integrity by stabilizing cohesin complex. Nucleic acids research, 2023; 51:7376-7391.
6. Yingzi Cui, Ye Qi, Li Ding, Shuangjin Ding, Zonglin Han, Yangming Wang* and Peng Du*. miRNA dosage control in development and human disease. Trends in Cell Biology, 2023; DOI: https://doi.org/10.1016/j.tcb.2023.05.009. (Review)
7. Ye Qi, Li Ding, Siwen Zhang, Shengze Yao, Jennie Ong, Yi Li, Hong Wu, and Peng Du* . A plant immune protein enables broad antitumor response by rescuing microRNA deficiency in cancers. Cell, 2022; 185:1888-1904.
8. Yanxin Li, Zhongqiu Li, Min Yang, Feiyang Wang, Yuehong Zhang, Rong Li, Qian Li, Yunxia Gong, Binhong Wang, Baoguang Fan, Chunyue Wang, Lei Chen, Hong Li, Jennie Ong, Zhaoqian Teng, Lei Jin*, Yan-Ling Wang*, Peng Du* and Jianwei Jiao*. Decoding the temporal and regional specification of microglia in the developing human brain. Cell Stem Cell, 2022; 29: 620-634.
9. Hui Shen, Min Yang, Shiyu Li, Jing Zhang, Bing Peng, Chunhui Wang, Zai Chang, Jennie Ong, and Peng Du*. Mouse totipotent stem cells captured and maintained through spliceosomal repression. Cell, 2021. 184:2843-2859.
10. Yingzi Cui, Xuehui Lyu, Li Ding, Lan Ke, Dechang Yang, Mehdi Pirouz, Ye Qi, Jennie Ong, Ge Gao, Peng Du*, and Richard Gregory*. Global miRNA dosage control of embryonic germ layer specification. Nature 2021; 593:602-606.
11. Bingqing Xie, Da Sun, Yuanyuan Du, Jun Jia, Shicheng Sun, Jun Xu, Yifang Liu, Chengang Xiang, Sitong Chen, Huangfan Xie, Qiming Wang, Guangya Li, Xuehui Lyu, Hui Shen, Shiyu Li, Min Wu, Xiaonan Zhang, Yue Pu, Kuanhui Xiang, Weifeng Lai, Peng Du, Zhenghong Yuan, Cheng Li, Yan Shi, Shichun Lu, Hongkui Deng. A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts. Cell research 2019; 29: 696-710.
a) 实验室成立前：
12. Junho Choe, Shuibin Lin, Wencai Zhang, Qi Liu, Longfei Wang, Julia Ramirez-Moya, Peng Du, Wantae Kim, Shaojun Tang, Piotr Sliz, Pilar Santisteban, Rani E George, William G Richards, Kwok-Kin Wong, Nicolas Locker, Frank J Slack, Richard I Gregory. mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis. Nature， 2018; 561:556-560.
13. Hee Ho Park, Robinson Triboulet, Martin Bentler, Swaroopa Guda, Peng Du, Haiming Xu, Richard I Gregory, Christian Brendel, David A Williams. Drosha knockout leads to enhancement of viral titers for vectors encoding miRNA-adapted shRNAs. Molecular Therapy, 2018; 12:591-599.
14. Peng Du, Mehdi Pirouz, Jiho Choi, Aaron J Huebner, Kendell Clement, Alexander Meissner, Konrad Hochedlinger, Richard I Gregory. An intermediate pluripotent state controlled by microRNAs is required for the naive-to-primed stem cell transition. Cell Stem Cell, 2018; 22:851-864.
15. Mehdi Pirouz, Peng Du, Marzia Munafò, Richard I Gregory. Dis3l2-mediated decay is a quality control pathway for noncoding RNAs. Cell Reports, 2016; 16:1861-73.
16. Shuibin Lin, Junho Choe, Peng Du, Robinson Triboulet, Richard I Gregory. METTL3 promotes translation in human cancer cells. Molecular Cell, 2016; 62:335-45.
17. Peng Du, Longfei Wang, Piotr Sliz, Richard I Gregory. A biogenesis step upstream of microprocessor controls miR-17∼92 expression. Cell 2015; 162:885-99.
18. Swaroopa Guda, Christian Brendel, Raffaele Renella, Peng Du, Daniel E Bauer, Matthew C Canver, Jennifer K Grenier, Andrew W Grimson, Sophia C Kamran, James Thornton, Helen de Boer, David E Root, Michael D Milsom, Stuart H Orkin, Richard I Gregory, David A Williams. miRNA-embedded shRNAs for lineage-specific BCL11A knockdown and hemoglobin F induction. Molecular Therapy, 2015; 10.1038.
19. James E Thornton, Peng Du, Lili Jing, Ljiljana Sjekloca, Shuibin Lin, Elena Grossi, Piotr Sliz, Leonard I Zon, Richard I Gregory. Selective microRNA uridylation by Zcchc6 (TUT7) and Zcchc11 (TUT4). Nucleic Acids Res, 2014; 42:11777-91.
20. Mengji Cao#, Peng Du#, Xianbing Wang, Yun-Qi Yu, Yan-Hong Qiu, Wanxiang Li, Amit Gal-On, Changyong Zhou, Yi Li, Shou-Wei Ding. Virus infection triggers widespread silencing of host genes by a distinct class of endogenous siRNAs in Arabidopsis. PNAS, 2014; 111:14613-8.
21. Peng Du#, Jianguo Wu#, Jiayao Zhang, Shuqi Zhao, Hong Zheng, Ge Gao, Liping Wei, Yi Li. Viral infection induces expression of novel phased microRNAs from conserved cellular microRNA precursors. PLoS Pathogens, 2011; 7:e1002176.
执教课程
生命科学原理与前沿（本），秋季
高级遗传学（研、CLS），秋季
发育生物学（研、PTN），春季
细胞衰老与死亡（研），春季
高级遗传学（研、CLS），秋季
发育生物学（研、PTN），春季
细胞衰老与死亡（研），春季
实验室简介
我们的研究集中于干细胞与转化医学中的RNA生物学。
在干细胞研究方面，实验室最近的研究通过对于剪接体（splicesoeme）的抑制，实现了迄今为止分化潜能最高的人类和小鼠的全能性胚胎干细胞的捕获和培养 (Cell, 2021; Cell, 2024)。在此基础上，我们将进一步对该培养条件进行优化，以期最终获得不同物种来源的全能性干细胞的体外培养。继而全能性干细胞为起始细胞，探索其分化到不同种类的功能细胞及类器官的分化体系，并进行动物个体的从头合成和重构，从而最终获得可应用于再生医学的高质量细胞和器官。
实验室也利用基础的生物化学和分子生物学的手段鉴定和发现新型的RNA调控通路。实验室最新的研究发现了一种通过基因转录起始事件介导的的微小RNA（microRNA）的整体剂量调控机制，以及该机制在早期胚胎发育三胚层命运决定中的关键作用 (Nature, 2021)。未来我们继续致力于发现和鉴定决定细胞分化命运及肿瘤发生过程中的核心RNA介导的调控通路，并解析其生理学功能。
我们在尝试利用已知相关知识进行跨物种基因工程应用的相关研究。比如我们最近利用一种植物特异免疫蛋白RDR，实现了对于肿瘤细胞中有缺陷的miRNA的特异编辑和修复，恢复了miRNA对于肿瘤细胞增值的广谱抑制，开发了肿瘤治疗的新方案 (Cell, 2022)。
最后我们也广泛利用单细胞转录组及空间转录组等高通量测序技术，解析早期胚胎发育过程及儿童肿瘤发生过程中发育及肿瘤微环境的建立及稳态维持，并试图找到决定早期胚胎发育及疾病发生过程的决定的关键环境因子及事件（Cell Stem Cell, 2022; Cell, 2023a; Cell, 2023b)。
