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个人简历
教育经历
1991年 - 1997年 , 理学博士 , 生物物理学 , 美国威斯康星-麦迪逊大学
1985年 - 1989年 , 理学学士 , 生理学及生物物理学 , 北京大学
1985年 - 1989年 , 理学学士 , 生理学及生物物理学 , 北京大学
工作经历
2001年 - 至今 北京大学长江特聘教授、北京大学生命科学学院 生物化学与分子生物学专业博士生导师
1997年 - 2001年 博士后 美国 The Scripps Research Institute
1997年 - 2001年 博士后 美国 The Scripps Research Institute
荣誉奖励
教育部“长江学者奖励计划”特聘教授，2001年
国家自然科学基金委杰出青年基金获得者，2001年
国家自然科学基金委杰出青年基金获得者，2001年
杂志任职
《波谱学》杂志编委
《Journal of Biological Chemistry》杂志编委
《Journal of Biological Chemistry》杂志编委
科研领域描述
液体核磁共振技术（NMR）是解析生物大分子高分辨率三维空间结构的重要研究手段，其特点是能够在与生理环境非常相近的溶液环境中研究生物大分子的三维结构，同时还是研究生物大分子的动态性质、生物大分子之间及与小分子相互作用的重要手段。本实验室研究兴趣在于利用液相核磁共振手段结合分子生物学、细胞生物学、分析化学等方法，研究蛋白质、DNA等生物大分子的结构、功能和作用机理。揭示生物大分子在肿瘤发生发展、致病菌基因表达调控、致病及功能性淀粉样蛋白聚集等重要生命过程中发挥的功能及其分子机制。
代表性论文
1. Q. Huang, B. Duan, X. Dong*, S. Fan*, B. Xia*. GapR binds DNA through dynamic opening of its tetrameric interface. Nucleic Acids Research. 48, 9372-9386(2020)
2. Y. Liao, B. Duan, Y. Zhang, X. Zhang, B. Xia*. Excessive ER-phagy mediated by the autophagy receptor FAM134B results in ER stress, the unfolded protein response, and cell death in HeLa cells. J Biol Chem. 294(52):20009-20023(2019)
3. B. Duan, P. Ding, T. R. Hughes, W. W. Navarre, J. Liu, B. Xia*. How Bacterial Xenogeneic Silencer Rok Distinguishes Foreign from Self DNA in Its Resident Genome. Nucleic Acids Research. 46, 10514-10529(2018)
4. S. Jin, P. Ding, P. Chu, H. Li, J. Sun, D. Liang, F. Song, B. Xia*. Zn(II) can mediate self-association of the extracellular C-terminal domain of CD147. Protein & Cell. 9, 310–315(2018).
5. P. Ding, X. Zhang, S. Jin, B. Duan, P. Chu, Y. Zhang, Z. Chen, B. Xia*, F. Song*. CD147 functions as the signaling receptor for extracellular divalent copper in hepatocellular carcinoma cells. Oncotarget. 8,51151-51163(2017).
6. Y. Kuang, K. Ma, C. Zhou, P. Ding, Y. Zhu, Q. Chen, B. Xia*. Structural basis for the phosphorylation of FUNDC1 LIR as a molecular switch of mitophagy. Autophagy. 12,2363-2373(2016)
7. P. Ding, K. A. McFarland, S. Jin, G. Tong, B. Duan, A. Yang, T. R. Hughes, J. Liu, S. L. Dove*, W. W. Navarre*, B. Xia*. A Novel AT-Rich DNA Recognition Mechanism for Bacterial Xenogeneic Silencer MvaT. PLoS Pathogens. 11, e1004967(2015)
8. X. Kang, N. Zhong, P. Zou, S. Zhang, C. Jin, B. Xia*. "Foldon unfolding mediates the interconversion between Mpro-C monomer and 3D domain-swapped dimer", Proc Natl Acad Sci U S A, 84, 9721-8(2012).
9. B. R.G. Gordon, Y Li, A. Coteb, M. T. Weirauch, P. Ding, T. R. Hughes, W. W. Navarre, B. Xia*, and J. Liu* “Structural basis for recognition of AT-rich DNA by unrelated xenogeneic silencing proteins”, Proc Natl Acad Sci U S A. 108, 10690-5(2011).
10. S. Tian, J. Lin, J. Zhou, X. Wan, Y. Li, X. Ren, W. Yu, W. Zhong, J. Xiao, F. Sheng, Y. Chen, C. Jin, S. Li, Z. Zheng*, and B. Xia* “Beclin 1-independent autophagy induced by a Bcl-XL/Bcl-2 targeting compound Z18”, Autophagy 6: 1032-41 (2010).
11. B. R.G. Gordon, Y. Li , L. Wang , A. Sintsova , H. V. Bakel , S. Tian, W. W. Navarre, B. Xia*, and J. Liu* “Lsr2 is A Nucleoid-Associated Protein that Targets AT-Rich Sequences and Virulence Genes in Mycobacterium tuberculosis”, Proc. Natl. Acad. Sci. 107: 5154-5159 (2010).
12. S. Zhang, N. Zhong, F. Xue, X. Kang, X. Ren, J. Chen, C. Jin, Z. Lou and B. Xia* “3D domain swapping as a mechanism to lock the active conformation in a super-active octamer of SARS-CoV main protease”, Protein Cell 1: 371–83 (2010).
2. Y. Liao, B. Duan, Y. Zhang, X. Zhang, B. Xia*. Excessive ER-phagy mediated by the autophagy receptor FAM134B results in ER stress, the unfolded protein response, and cell death in HeLa cells. J Biol Chem. 294(52):20009-20023(2019)
3. B. Duan, P. Ding, T. R. Hughes, W. W. Navarre, J. Liu, B. Xia*. How Bacterial Xenogeneic Silencer Rok Distinguishes Foreign from Self DNA in Its Resident Genome. Nucleic Acids Research. 46, 10514-10529(2018)
4. S. Jin, P. Ding, P. Chu, H. Li, J. Sun, D. Liang, F. Song, B. Xia*. Zn(II) can mediate self-association of the extracellular C-terminal domain of CD147. Protein & Cell. 9, 310–315(2018).
5. P. Ding, X. Zhang, S. Jin, B. Duan, P. Chu, Y. Zhang, Z. Chen, B. Xia*, F. Song*. CD147 functions as the signaling receptor for extracellular divalent copper in hepatocellular carcinoma cells. Oncotarget. 8,51151-51163(2017).
6. Y. Kuang, K. Ma, C. Zhou, P. Ding, Y. Zhu, Q. Chen, B. Xia*. Structural basis for the phosphorylation of FUNDC1 LIR as a molecular switch of mitophagy. Autophagy. 12,2363-2373(2016)
7. P. Ding, K. A. McFarland, S. Jin, G. Tong, B. Duan, A. Yang, T. R. Hughes, J. Liu, S. L. Dove*, W. W. Navarre*, B. Xia*. A Novel AT-Rich DNA Recognition Mechanism for Bacterial Xenogeneic Silencer MvaT. PLoS Pathogens. 11, e1004967(2015)
8. X. Kang, N. Zhong, P. Zou, S. Zhang, C. Jin, B. Xia*. "Foldon unfolding mediates the interconversion between Mpro-C monomer and 3D domain-swapped dimer", Proc Natl Acad Sci U S A, 84, 9721-8(2012).
9. B. R.G. Gordon, Y Li, A. Coteb, M. T. Weirauch, P. Ding, T. R. Hughes, W. W. Navarre, B. Xia*, and J. Liu* “Structural basis for recognition of AT-rich DNA by unrelated xenogeneic silencing proteins”, Proc Natl Acad Sci U S A. 108, 10690-5(2011).
10. S. Tian, J. Lin, J. Zhou, X. Wan, Y. Li, X. Ren, W. Yu, W. Zhong, J. Xiao, F. Sheng, Y. Chen, C. Jin, S. Li, Z. Zheng*, and B. Xia* “Beclin 1-independent autophagy induced by a Bcl-XL/Bcl-2 targeting compound Z18”, Autophagy 6: 1032-41 (2010).
11. B. R.G. Gordon, Y. Li , L. Wang , A. Sintsova , H. V. Bakel , S. Tian, W. W. Navarre, B. Xia*, and J. Liu* “Lsr2 is A Nucleoid-Associated Protein that Targets AT-Rich Sequences and Virulence Genes in Mycobacterium tuberculosis”, Proc. Natl. Acad. Sci. 107: 5154-5159 (2010).
12. S. Zhang, N. Zhong, F. Xue, X. Kang, X. Ren, J. Chen, C. Jin, Z. Lou and B. Xia* “3D domain swapping as a mechanism to lock the active conformation in a super-active octamer of SARS-CoV main protease”, Protein Cell 1: 371–83 (2010).
