当前位置：
 |
|
|||||||||||
个人简历
教育经历
1999 - 2002 , 博士后 , 美国加州大学洛杉矶分校医学院
1998 - 1999 , 博士后 , 日本东京大学医学部
1995 - 1998 , 理学博士 , 细胞生物学系 , 北京大学生命科学学院
1992 - 1995 , 理学硕士 , 细胞生物学系 , 北京大学生命科学学院
1988 - 1992 , 理学学士 , 细胞生物学专业 , 北京大学生物学系
1998 - 1999 , 博士后 , 日本东京大学医学部
1995 - 1998 , 理学博士 , 细胞生物学系 , 北京大学生命科学学院
1992 - 1995 , 理学硕士 , 细胞生物学系 , 北京大学生命科学学院
1988 - 1992 , 理学学士 , 细胞生物学专业 , 北京大学生物学系
工作经历
2017年8月起 北京大学生命科学学院 教授，博士生导师，
2002 - 2017 北京大学生命科学学院 副教授
1998 - 2002 北京大学生命科学学院 讲师
2002 - 2017 北京大学生命科学学院 副教授
1998 - 2002 北京大学生命科学学院 讲师
社会服务工作
1. 2006 - 2010 , 教育部基础生物科学教学指导委员会 秘书长
2. 2005 - 至今 , 全国中学生生物竞赛委员会委员
2. 2005 - 至今 , 全国中学生生物竞赛委员会委员
荣誉奖励
北京大学教学优秀奖，2016
北京大学教学优秀奖, 2012
北京大学教学演示竞赛一等奖 , 2012
北京大学教学优秀奖 , 2010
首都教育先锋——教学创新先进个人 , 2009
教育部“新世纪优秀人才支持计划”入选者 , 2008
第十届霍英东青年教师奖（研究类三等奖） , 2006
北京大学“东宝”奖教金 , 2005
北京大学教学优秀奖 , 2003
北京大学教学优秀奖, 2012
北京大学教学演示竞赛一等奖 , 2012
北京大学教学优秀奖 , 2010
首都教育先锋——教学创新先进个人 , 2009
教育部“新世纪优秀人才支持计划”入选者 , 2008
第十届霍英东青年教师奖（研究类三等奖） , 2006
北京大学“东宝”奖教金 , 2005
北京大学教学优秀奖 , 2003
科研领域描述
本实验室主要兴趣在于：
主要兴趣是斑马鱼内部器官的形成，尤其是心血管系统的发育，并以此为基础，研究人类先天性心脏病的发病机理。
斑马鱼是研究脊椎动物发育和人类疾病的理想模式生物。随着斑马鱼基因组计划的接近完成，我们面临着研究将近30,000个在斑马鱼和其他脊椎动物都保守的基因的功能及其调控的艰巨任务。正向遗传学的诱变技术、反向遗传学的TALEN技术、CRISPR/Cas9技术以及基于TALEN的同源重组技术都已在斑马鱼中得到成功地应用，可以随心所欲地将斑马鱼的任何基因修饰为任何形式，为研究基因功能提供了完美的利器。
主要兴趣是斑马鱼内部器官的形成，尤其是心血管系统的发育，并以此为基础，研究人类先天性心脏病的发病机理。
斑马鱼是研究脊椎动物发育和人类疾病的理想模式生物。随着斑马鱼基因组计划的接近完成，我们面临着研究将近30,000个在斑马鱼和其他脊椎动物都保守的基因的功能及其调控的艰巨任务。正向遗传学的诱变技术、反向遗传学的TALEN技术、CRISPR/Cas9技术以及基于TALEN的同源重组技术都已在斑马鱼中得到成功地应用，可以随心所欲地将斑马鱼的任何基因修饰为任何形式，为研究基因功能提供了完美的利器。
代表性论文
1. Tong X*#, Zu Y*, Li Z*, Li W, Ying L, Yang J, Wang X, He S, Liu D, Zhu Z, Chen J, Lin S, Zhang B. , Kctd10 regulates heart morphogenesis by repressing the transcriptional activity of Tbx5a in zebrafish. , Nat. Commun. , 2014 , 5:3153. doi: 10.1038/ncomms4153.,*共同第一作者；#通讯作者
2. Xia Z, Tong X, Liang F, Zhang Y, Kuok C, Zhang Y, Liu X, Zhu Z, Lin S, Zhang B. , Eif3ba regulates cranial neural crest development by modulating p53 in zebrafish. , Dev Biol. , 2013 , 381(1):83-96
3. Xiao A, Wang Z, Hu Y, Wu Y, Luo Z, Yang Z, Zu Y, Li W, Huang P, Tong X, Zhu Z, Lin S, Zhang B. , Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish. , Nucleic Acids Res. , 2013 , 1;41(14):e141
4. Zu Y*, Tong X*, Wang Z, Liu D, Pan R, Li Z, Hu Y, Luo Z, Huang P, Wu Q, Zhu Z, Zhang B, Lin S. , TALEN mediated precise genome modification by homologous recombination in zebrafish. , Nat. Methods , 2013 , 10(4):329-31,*共同第一作者 （封面文章并配发评论）
5. Tong X*, Xia Z*, Zu Y, Telfer H, Hu J, Yu J, Liu H, Zhang Q, Sodmergen, Lin S, Zhang B. , ngs (Notochord Granular Surface) Gene Encodes a Novel Type of Intermediate Filament Family Protein Essential for Notochord Maintenance in Zebrafish. , J Biol Chem. , 2013 , 288(4):2711-20
6. Ji XD, Li G, Feng YX, Zhao JS, Li JJ, Sun ZJ, Shi S, Deng YZ, Xu JF, Zhu YQ, Koeffler HP, Tong XJ, Xie D. , EphB3 is overexpressed in non-small-cell lung cancer and promotes tumor metastasis by enhancing cell survival and migration. , Cancer Res. , 2011 , 71(3):1156-66
7. Sun ZJ, Wang Y, Cai Z, Chen PP, Tong XJ, Xie D. , Involvement of Cyr61 in growth, migration and metastasis of prostate cancer cells. , Br J Cancer. , 2008 , 99(10):1656-67
8. Wang Y, Liu D, Chen P, Koeffler HP, Tong X, Xie D. , Negative feedback regulation of IFN-gamma pathway by IFN regulatory factor 2 in esophageal cancers. , Cancer Res. , 2008 , 68(4):1136-43
9. Wang Y, Liu D, Chen PP, Koeffler HP, Tong X, and Xie D , Involvements of IFN Regulatory Factor-1 and IFN Regulatory Factor-2 in the Formation and Progression of Human Esophageal Cancers. , Cancer Res , 2007 , 67: (6)：2535-43.
10. Deng YZ, Chen PP, Wang Y, Yin D, Koeffler HP, Li B, Tong XJ, Xie D. , Connective tissue growth factor is overexpressed in esophageal squamous cell carcinoma and promotes tumorigenicity through beta-catenin-T-cell factor/Lef signaling. , J Biol Chem. , 2007 , 282(50):36571-81.
11. Kawabata H, Tong X, Kawanami T, Wano Y, Hirose Y, Sugai S, Koeffler HP. , Analyses for binding of the transferrin family of proteins to the transferrin receptor 2. , Br J Haematol. , 2004 , 127(4):464-73
12. Kumagai T, Ikezoe T, Gui D, O`Kelly J, Tong XJ, Cohen FJ, Said JW, Koeffler HP. , RWJ-241947 (MCC-555), a unique peroxisome proliferator-activated receptor-gamma ligand with antitumor activity against human prostate cancer in vitro and in beige/nude/ X-linked immunodeficient mice and enhancement of apoptosis in myeloma cells induced by , Clin Cancer Res. , 2004 , 10(4):1508-20
13. Tong X, O`Kelly J, Xie D, Mori A, Lemp N, McKenna R, Miller CW, Koeffler HP , Cyr61 suppresses the growth of non-small-cell lung cancer cells via the beta-catenin-c-myc-p53 pathway , Oncogene , 2004 , 23(28):4847-55
14. Xie D, Yin D, Tong X, O`Kelly J, Mori A, Miller C, Black K, Gui D, Said JW, Koeffler HP , Cyr61 is overexpressed in gliomas and involved in integrin-linked kinase-mediated Akt and beta-catenin-TCF/Lef signaling pathways , Cancer Res. , 2004 , 64(6):1987-96
15. Tong X, Xie D, Roth W, Reed J, Koeffler HP , NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo , Int J Oncol. , 2003 , 22(6): 1357-62
16. Hoffman WK, Tong XJ, Ajioka RS, Kushner JP, Koeffler HP , Mutation analysis of transferrin-receptor 2 in patients with atypical hemochromatosis , Blood , 2002 , 100 (3): 1099-100
17. Tong X, Kawabata H, Koeffler HP. , Iron deficiency can upregulate expression of transferrin receptor at both the mRNA and protein level , Br J Haematol. , 2002 , 116(2):458-64
18. Tong X, Xie D, O`Kelly J, Miller CW, Muller-Tidow C, Koeffler HP. , Cyr61, a member of CCN family, is a tumor suppressor in non-small cell lung cancer. , J Biol Chem. , 2001 , 276(50):47709-14
19. Kawabata H, Germain RS, Ikezoe T, Tong X, Green EM, Gombart AF, Koeffler HP , Regulation of expression of murine transferrin receptor 2 , Blood , 2001 , 98(6):1949-54
2. Xia Z, Tong X, Liang F, Zhang Y, Kuok C, Zhang Y, Liu X, Zhu Z, Lin S, Zhang B. , Eif3ba regulates cranial neural crest development by modulating p53 in zebrafish. , Dev Biol. , 2013 , 381(1):83-96
3. Xiao A, Wang Z, Hu Y, Wu Y, Luo Z, Yang Z, Zu Y, Li W, Huang P, Tong X, Zhu Z, Lin S, Zhang B. , Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish. , Nucleic Acids Res. , 2013 , 1;41(14):e141
4. Zu Y*, Tong X*, Wang Z, Liu D, Pan R, Li Z, Hu Y, Luo Z, Huang P, Wu Q, Zhu Z, Zhang B, Lin S. , TALEN mediated precise genome modification by homologous recombination in zebrafish. , Nat. Methods , 2013 , 10(4):329-31,*共同第一作者 （封面文章并配发评论）
5. Tong X*, Xia Z*, Zu Y, Telfer H, Hu J, Yu J, Liu H, Zhang Q, Sodmergen, Lin S, Zhang B. , ngs (Notochord Granular Surface) Gene Encodes a Novel Type of Intermediate Filament Family Protein Essential for Notochord Maintenance in Zebrafish. , J Biol Chem. , 2013 , 288(4):2711-20
6. Ji XD, Li G, Feng YX, Zhao JS, Li JJ, Sun ZJ, Shi S, Deng YZ, Xu JF, Zhu YQ, Koeffler HP, Tong XJ, Xie D. , EphB3 is overexpressed in non-small-cell lung cancer and promotes tumor metastasis by enhancing cell survival and migration. , Cancer Res. , 2011 , 71(3):1156-66
7. Sun ZJ, Wang Y, Cai Z, Chen PP, Tong XJ, Xie D. , Involvement of Cyr61 in growth, migration and metastasis of prostate cancer cells. , Br J Cancer. , 2008 , 99(10):1656-67
8. Wang Y, Liu D, Chen P, Koeffler HP, Tong X, Xie D. , Negative feedback regulation of IFN-gamma pathway by IFN regulatory factor 2 in esophageal cancers. , Cancer Res. , 2008 , 68(4):1136-43
9. Wang Y, Liu D, Chen PP, Koeffler HP, Tong X, and Xie D , Involvements of IFN Regulatory Factor-1 and IFN Regulatory Factor-2 in the Formation and Progression of Human Esophageal Cancers. , Cancer Res , 2007 , 67: (6)：2535-43.
10. Deng YZ, Chen PP, Wang Y, Yin D, Koeffler HP, Li B, Tong XJ, Xie D. , Connective tissue growth factor is overexpressed in esophageal squamous cell carcinoma and promotes tumorigenicity through beta-catenin-T-cell factor/Lef signaling. , J Biol Chem. , 2007 , 282(50):36571-81.
11. Kawabata H, Tong X, Kawanami T, Wano Y, Hirose Y, Sugai S, Koeffler HP. , Analyses for binding of the transferrin family of proteins to the transferrin receptor 2. , Br J Haematol. , 2004 , 127(4):464-73
12. Kumagai T, Ikezoe T, Gui D, O`Kelly J, Tong XJ, Cohen FJ, Said JW, Koeffler HP. , RWJ-241947 (MCC-555), a unique peroxisome proliferator-activated receptor-gamma ligand with antitumor activity against human prostate cancer in vitro and in beige/nude/ X-linked immunodeficient mice and enhancement of apoptosis in myeloma cells induced by , Clin Cancer Res. , 2004 , 10(4):1508-20
13. Tong X, O`Kelly J, Xie D, Mori A, Lemp N, McKenna R, Miller CW, Koeffler HP , Cyr61 suppresses the growth of non-small-cell lung cancer cells via the beta-catenin-c-myc-p53 pathway , Oncogene , 2004 , 23(28):4847-55
14. Xie D, Yin D, Tong X, O`Kelly J, Mori A, Miller C, Black K, Gui D, Said JW, Koeffler HP , Cyr61 is overexpressed in gliomas and involved in integrin-linked kinase-mediated Akt and beta-catenin-TCF/Lef signaling pathways , Cancer Res. , 2004 , 64(6):1987-96
15. Tong X, Xie D, Roth W, Reed J, Koeffler HP , NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo , Int J Oncol. , 2003 , 22(6): 1357-62
16. Hoffman WK, Tong XJ, Ajioka RS, Kushner JP, Koeffler HP , Mutation analysis of transferrin-receptor 2 in patients with atypical hemochromatosis , Blood , 2002 , 100 (3): 1099-100
17. Tong X, Kawabata H, Koeffler HP. , Iron deficiency can upregulate expression of transferrin receptor at both the mRNA and protein level , Br J Haematol. , 2002 , 116(2):458-64
18. Tong X, Xie D, O`Kelly J, Miller CW, Muller-Tidow C, Koeffler HP. , Cyr61, a member of CCN family, is a tumor suppressor in non-small cell lung cancer. , J Biol Chem. , 2001 , 276(50):47709-14
19. Kawabata H, Germain RS, Ikezoe T, Tong X, Green EM, Gombart AF, Koeffler HP , Regulation of expression of murine transferrin receptor 2 , Blood , 2001 , 98(6):1949-54
执教课程
遗传学 , 讲课 , 北京大学 , 春季学期
普通生物学A , 讲课 , 北京大学 , 全年
普通生物学A , 讲课 , 北京大学 , 全年
实验室简介
以斑马鱼（Danio rerio）为模式动物，开发并完善以CRISPR/Cas为基础的基因组编辑技术，结合单细胞测序等技术，研究心血管、胰腺等组织器官发育与再生的遗传基础及其基因表达调控机制，建立人类疾病的斑马鱼模型并进行发病机制研究。
