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个人简历
个人介绍文字
陈雪梅教授1988年获得北京大学学士学位，1995年获得美国康奈尔大学博士学位，随后在加州理工学院进行博士后研究。她于1999年在罗格斯大学瓦克斯曼研究所担任助理教授，于2005年晋升为副教授，并获得罗格斯大学董事会学术卓越研究奖。她于2005年转至加州大学河滨分校，任副教授，2009年晋升为正教授，2013年晋升为特聘教授。2023年，任北京大学讲席教授。2006年获美国植物生物学家协会颁发的的查尔斯·阿尔伯特·舒尔奖，2011年当选为AAAS研究员，2012年至2018年任HHMI-GBMF研究员。2013年当选为美国国家科学院院士。2016年于加州大学河滨分校获得大学讲师奖，该奖项为教师每年因研究卓越而获得的最高荣誉。2018年获得了南加州华裔科学家和工程师协会的成就奖。她的工作重点是花的发育、小RNA和植物的RNA修饰。
教育经历
1984-1988 学士，北京大学
1989-1995 博士，美国康奈尔大学
1989-1995 博士，美国康奈尔大学
工作经历
2023- 院长，北京大学生命科学学院
2023- 特聘教授，北京大学
2013-2023 特聘教授，加州大学河滨分校
2009-2013 教授，加州大学河滨分校
2005-2009 副教授，加州大学河滨分校
1999-2005 助理教授，美国罗格斯大学 （新泽西州立大学）
1995-1998 博士后，美国加州理工学院
2023- 特聘教授，北京大学
2013-2023 特聘教授，加州大学河滨分校
2009-2013 教授，加州大学河滨分校
2005-2009 副教授，加州大学河滨分校
1999-2005 助理教授，美国罗格斯大学 （新泽西州立大学）
1995-1998 博士后，美国加州理工学院
社会服务工作
Member of the North American Arabidopsis Steering Committee, 2005-2008.
Member of review committee of Shanghai Institute of Plant Physiology and Ecology, 2009.
Board member of International Botanical Congress (2017) scientific program committee
Scientific Advisory Board member for the International Arabidopsis Informatics Consortium (IAIC), 2012-2015
Scientific Advisory Board member for the joint center of Chinese Academy of Sciences and John Innes Center (UK), 2016 - 2017
Ray Wu Prize committee, 2015 - present
Board of Advisors, IPMB congress 2022
Keystone symposia study group for 2022-2023 programs
Keystone symposia Scientific Advisory Board for 2024-2025 programs
Member of review committee of Shanghai Institute of Plant Physiology and Ecology, 2009.
Board member of International Botanical Congress (2017) scientific program committee
Scientific Advisory Board member for the International Arabidopsis Informatics Consortium (IAIC), 2012-2015
Scientific Advisory Board member for the joint center of Chinese Academy of Sciences and John Innes Center (UK), 2016 - 2017
Ray Wu Prize committee, 2015 - present
Board of Advisors, IPMB congress 2022
Keystone symposia study group for 2022-2023 programs
Keystone symposia Scientific Advisory Board for 2024-2025 programs
荣誉奖励
2018 Achievement Award, Chinese American Association of Scientists and Engineers of Southern California
2016 University Faculty Lecturer, UC Riverside
2013 Elected to the US National Academy of Sciences
2011 Elected an AAAS Fellow
2012-2018 HHMI-GBMF investigator
2007-2010 University Scholar, UC Riverside
2006 Charles Albert Shull award from American Society of Plant Biologists
2005 Board of Trustees Research Fellowship for Scholarly Excellence, Rutgers University
2002-2002 March of Dimes Basil O`Connor Starter Scholar Research Award
1995-1997 NIH Postdoctoral Fellowship
1991-1994 Cornell Plant Science Center Fellowship
1992 The Liu Memorial Award and The Hsien Wu and Daisy Yen Wu Scholarship
2016 University Faculty Lecturer, UC Riverside
2013 Elected to the US National Academy of Sciences
2011 Elected an AAAS Fellow
2012-2018 HHMI-GBMF investigator
2007-2010 University Scholar, UC Riverside
2006 Charles Albert Shull award from American Society of Plant Biologists
2005 Board of Trustees Research Fellowship for Scholarly Excellence, Rutgers University
2002-2002 March of Dimes Basil O`Connor Starter Scholar Research Award
1995-1997 NIH Postdoctoral Fellowship
1991-1994 Cornell Plant Science Center Fellowship
1992 The Liu Memorial Award and The Hsien Wu and Daisy Yen Wu Scholarship
杂志任职
Senior editor, The Plant Cell, 04/2020 – present
Consulting Editor of PLOS Genetics, January 2016 - present
Editorial Board member of National Science Review 2015 – present
Editorial Board member of Molecular Plant, December 2014 – present
Editorial Board member of China Science Bulletin, 2014 – present
Editorial Board member of Science in China, 2014 - present
Editorial Board member of PLOS Biology, June 2014-present
Editorial Board member of Genes & Development, 2013-2017
Associate Editor of PLOS Genetics, Nov 2012 – January 2016
Editor of Plant Journal, January 2010 – December 2015
Editor of Molecular Plant, January 2012 – December 2014
Editorial Board member of Current Opinion in Plant Biology, December 2007 – present
Editor of Tropical Plant Biology, August 2007 – present
Monitoring Editor of Plant Physiology, August 2005 – December 2009
Editorial Board member of RNA Biology, 2004 - present
Consulting Editor of PLOS Genetics, January 2016 - present
Editorial Board member of National Science Review 2015 – present
Editorial Board member of Molecular Plant, December 2014 – present
Editorial Board member of China Science Bulletin, 2014 – present
Editorial Board member of Science in China, 2014 - present
Editorial Board member of PLOS Biology, June 2014-present
Editorial Board member of Genes & Development, 2013-2017
Associate Editor of PLOS Genetics, Nov 2012 – January 2016
Editor of Plant Journal, January 2010 – December 2015
Editor of Molecular Plant, January 2012 – December 2014
Editorial Board member of Current Opinion in Plant Biology, December 2007 – present
Editor of Tropical Plant Biology, August 2007 – present
Monitoring Editor of Plant Physiology, August 2005 – December 2009
Editorial Board member of RNA Biology, 2004 - present
评审任职
Ad hoc reviewer for ERC (Europe), 2022
NIH MIRA panel June 23-24, 2020
NIFA panel, July 2013
NIH DEV1 study section regular member, 2012-2016
NSF review panel, Sept 2012
Served on NIH DEV1 panel, Oct 2011
Served on NIH study section (DEV1), Feb 14-15, 2008.
Served as an ad hoc reviewer on NIH study section, Oct. 2006.
Served on NSF panel, 2005
Served on NASA plant biology panel, March 2001
NIH MIRA panel June 23-24, 2020
NIFA panel, July 2013
NIH DEV1 study section regular member, 2012-2016
NSF review panel, Sept 2012
Served on NIH DEV1 panel, Oct 2011
Served on NIH study section (DEV1), Feb 14-15, 2008.
Served as an ad hoc reviewer on NIH study section, Oct. 2006.
Served on NSF panel, 2005
Served on NASA plant biology panel, March 2001
会议发言与组织
Co-organized the Keystone symposium “Nuclear events in plant gene expression and signaling”, March 6-10, 2012, Taos, New Mexico.
Co-organized the Cold Spring Harbor Asia meeting on RNA biology, Nov 1-5, 2010, Suzhou, China.
Co-organized the 19th International Conference for Arabidopsis Research, July 23-27, 2008, Montreal, Canada.
Co-organized the 24th symposium in plant biology titled “Gene silencing: small RNAs and the epigenome”, Riverside, Jan. 2007.
Keynote speaker, The 23rd Penn State Symposium in Plant Biology – RNA Biology. May 18-20, 2022. Noncanonical RNA caps - NAD, FAD, and dpCoA
Keynote speaker, Cold Spring Harbor Laboratory symposium - Plant Genomes, Systems of Biology & Engineering. December 1-4, 2021.
Plenary speaker at NSF-sponsored workshop: Cross-disciplinary study of post-transcriptional and post-translational modifications, October 18-20, 2021. Virtual.
Plenary session organizer and speaker, ASPB Plant Biology21, July 2021. Session title: RNA - the long and short of it
Distinguished lecture, City University of Hong Kong, December 19, 2017
Keynote address, the 19th International Botanical Congress, Shenzhen, China. July 23-29, 2017.
Keynote speech, the 57th International Maize Conference, St. Charles, Illinois. March 12-15, 2015.
Plenary speech, Plant and Animal Genome (PAG) XXIII, San Diego, Jan 9-14, 2015.
Keynote speech, The 25th International Conference on Arabidopsis Research, Vancouver, Canada. July 28-August 1, 2014.
Co-organized the Cold Spring Harbor Asia meeting on RNA biology, Nov 1-5, 2010, Suzhou, China.
Co-organized the 19th International Conference for Arabidopsis Research, July 23-27, 2008, Montreal, Canada.
Co-organized the 24th symposium in plant biology titled “Gene silencing: small RNAs and the epigenome”, Riverside, Jan. 2007.
Keynote speaker, The 23rd Penn State Symposium in Plant Biology – RNA Biology. May 18-20, 2022. Noncanonical RNA caps - NAD, FAD, and dpCoA
Keynote speaker, Cold Spring Harbor Laboratory symposium - Plant Genomes, Systems of Biology & Engineering. December 1-4, 2021.
Plenary speaker at NSF-sponsored workshop: Cross-disciplinary study of post-transcriptional and post-translational modifications, October 18-20, 2021. Virtual.
Plenary session organizer and speaker, ASPB Plant Biology21, July 2021. Session title: RNA - the long and short of it
Distinguished lecture, City University of Hong Kong, December 19, 2017
Keynote address, the 19th International Botanical Congress, Shenzhen, China. July 23-29, 2017.
Keynote speech, the 57th International Maize Conference, St. Charles, Illinois. March 12-15, 2015.
Plenary speech, Plant and Animal Genome (PAG) XXIII, San Diego, Jan 9-14, 2015.
Keynote speech, The 25th International Conference on Arabidopsis Research, Vancouver, Canada. July 28-August 1, 2014.
杂志编辑
2012 Co-edited an issue on Plant Development, Current Opinion in Plant Biology
2010 Edited an issue in Seminars in Cell and Developmental Biology
2010 Edited an issue in Seminars in Cell and Developmental Biology
书籍编撰
Manu Agarwal, Julien Curaba, and Xuemei Chen*. (2009). Endogenous small RNA pathways in Arabidopsis. Chapter 11 in “Regulation of Gene Expression by Small RNAs”, edited by J. Rossi and J. Gaur, published by CRC press.
科研领域描述
早期研究植物花形态建成的基因调控机制，发现与RNA代谢相关的蛋白参与花器官分化。进而发现其中某些蛋白参与小RNA 代谢与功能。之后主要研究小RNA的生物合成， 降解，及作用机制。
目前的主要研究方向之一为小RNA的细胞间运输机制及作为信号分子调控植物响应温度变化的机制。第二个主要研究方向为RNA的非典型加帽修饰， 比如NAD， FAD， dpCoA 帽子的加入，去除机制及分子功能。第三个研究方向为叶绿体发育， 基因表达， 及RNA 修饰。
目前的主要研究方向之一为小RNA的细胞间运输机制及作为信号分子调控植物响应温度变化的机制。第二个主要研究方向为RNA的非典型加帽修饰， 比如NAD， FAD， dpCoA 帽子的加入，去除机制及分子功能。第三个研究方向为叶绿体发育， 基因表达， 及RNA 修饰。
代表性论文
Qing Sang, Lusheng Fan, Tianxiang Liu, YongjianQiu, Juan Du, Beixin Mo, Meng Chen*, and Xuemei Chen*. (2023). MicroRNA156 conditions auxin sensitivity to enable growth plasticity in response to environmental changes in Arabidopsis. Nature Comm., accepted.
Yuan Wang, Brandon H. Le, Jianqiang Wang, Chenjiang You, Yonghui Zhao, Mary Galli, Ye Xu, Andrea Gallavotti, Thomas Eulgem, Beixin Mo*, and Xuemei Chen*. (2022). A novel factor that recruits and excludes Pol IV-mediated DNA methylation in a site-specific manner. Science Advances 8, DOI: 10.1126/sciadv.adc9454.
Lusheng Fan, Cui Zhang, Yong Zhang, Ethan Stewart, Jakub Jez, Keiji Nakajima, and Xuemei Chen*. (2022). Microtubules promote the non-cell autonomous action of microRNAs by inhibiting their cytoplasmic loading onto ARGONAUTE1 in Arabidopsis. Dev. Cell. 57, 995-1008.
Xuemei Chen* and Oded Rechavi*. (2021). Plant and animal small RNA communications between cells and organisms. Nature Rev. Mol. Cell Biol. 23, 85–203.
Hao Hu, Nora Flynn, Hailei Zhang, Chenjiang You, Runlai Hang, Xufeng Wang, Huan Zhong, Zhulong Chan, Yiji Xia*, and Xuemei Chen*. (2021). SPAAC-NAD-seq, a sensitive and accurate method to profile NAD+-capped transcripts. PNAS 118 (13) e2025595118.
Zhenxia Su, Nannan Wang, Zhimin Hou, Baiyang Li, Dingning Li, Yanhui Liu, Hanyang Cai, Yuan Qin*, and Xuemei Chen*. (2020). Regulation of female germline specification via small RNA mobility in Arabidopsis. Plant Cell 32, 2842–2854.
Chenjiang You, Wenrong He, Runlai Hang, Cuiju Zhang, Xiaofeng Cao, Hongwei Guo, Xuemei Chen, Jie Cui*, and Beixin Mo*. (2019). FIERY1 promotes microRNA accumulation by suppressing rRNA-derived small interfering RNAs in Arabidopsis. Nature Comm. 10:4424.
Yuan Wang, Shaofang Li, Yonghui Zhao, Chenjiang You, Brandon Le, Zhizhong Gong, Beixin Mo, Yiji Xia and Xuemei Chen*. (2019). NAD+-capped RNAs are widespread in the Arabidopsis transcriptome and can probably be translated. PNAS 116, 12094-12102
Zhenxia Su, Lihua Zhao, Yuanyuan Zhao, Shaofang Li, So Youn Won, Hanyang Cai, Lulu Wang, Zhenfang Li, Yuan Qin*, and Xuemei Chen*. (2017). The THO complex non-cell autonomously represses female germline specification through the TAS3-ARF3 module. Current Biology 27, 1597–1609.
Yu Yu, Lijuan Ji, Brandon Le, Jixian Zhai, Jiayi Chen, Elizabeth Luscher, Lei Gao, Chunyan Liu, Xiaofeng Cao, Beixin Mo, Jinbiao Ma, Blake C. Meyers, and Xuemei Chen*. (2017). ARGONAUTE10 promotes the degradation of miR165/6 through the SDN1 and SDN2 exonucleases in Arabidopsis. PLoS Biology 15(2): e2001272.
Shengben Li, Lin Liu, Xiaohong Zhuang, Yu Yu, Xigang Liu, Xia Cui, Lijuan Ji, Zhiqiang Pan, Xiaofeng Cao, Beixin Mo, Fuchun Zhang, Natasha Raikhel, Liwen Jiang, and Xuemei Chen*. (2013). microRNAs inhibit the translation of target mRNAs on the endoplasmic reticulum in Arabidopsis. Cell 153, 562-574.
Yuanyuan Zhao, Yu Yu, Jixian Zhai, Vanitharani Ramachandran, Thanh Theresa Dinh, Blake C. Meyers, Beixin Mo*, and Xuemei Chen*. (2012). The Arabidopsis nucleotidyl transferase HESO1 uridylates unmethylated small RNAs to trigger their degradation. Current Biology 22, 689-694.
Vanitharani Ramachandran and Xuemei Chen*. (2008). Degradation of microRNAs by a family of exoribonucleases in Arabidopsis. Science 321, 1490-1492.
Junjie Li, Zhiyong Yang, Bin Yu, Jun Liu, and Xuemei Chen*. (2005). Methylation protects miRNAs and siRNAs from a 3’ end uridylation activity in Arabidopsis. Current Biology 15, 1501-1507.
Bin Yu, Zhiyong Yang, Junjie Li, Svetlana Minakhina, Maocheng Yang, Richard W. Padgett, Ruth Steward, and Xuemei Chen*. (2005). Methylation as a crucial step in plant microRNA biogenesis. Science 307, 932-935.
Xuemei Chen*. (2004). A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development. Science 303, 2022-2025.
Yuan Wang, Brandon H. Le, Jianqiang Wang, Chenjiang You, Yonghui Zhao, Mary Galli, Ye Xu, Andrea Gallavotti, Thomas Eulgem, Beixin Mo*, and Xuemei Chen*. (2022). A novel factor that recruits and excludes Pol IV-mediated DNA methylation in a site-specific manner. Science Advances 8, DOI: 10.1126/sciadv.adc9454.
Lusheng Fan, Cui Zhang, Yong Zhang, Ethan Stewart, Jakub Jez, Keiji Nakajima, and Xuemei Chen*. (2022). Microtubules promote the non-cell autonomous action of microRNAs by inhibiting their cytoplasmic loading onto ARGONAUTE1 in Arabidopsis. Dev. Cell. 57, 995-1008.
Xuemei Chen* and Oded Rechavi*. (2021). Plant and animal small RNA communications between cells and organisms. Nature Rev. Mol. Cell Biol. 23, 85–203.
Hao Hu, Nora Flynn, Hailei Zhang, Chenjiang You, Runlai Hang, Xufeng Wang, Huan Zhong, Zhulong Chan, Yiji Xia*, and Xuemei Chen*. (2021). SPAAC-NAD-seq, a sensitive and accurate method to profile NAD+-capped transcripts. PNAS 118 (13) e2025595118.
Zhenxia Su, Nannan Wang, Zhimin Hou, Baiyang Li, Dingning Li, Yanhui Liu, Hanyang Cai, Yuan Qin*, and Xuemei Chen*. (2020). Regulation of female germline specification via small RNA mobility in Arabidopsis. Plant Cell 32, 2842–2854.
Chenjiang You, Wenrong He, Runlai Hang, Cuiju Zhang, Xiaofeng Cao, Hongwei Guo, Xuemei Chen, Jie Cui*, and Beixin Mo*. (2019). FIERY1 promotes microRNA accumulation by suppressing rRNA-derived small interfering RNAs in Arabidopsis. Nature Comm. 10:4424.
Yuan Wang, Shaofang Li, Yonghui Zhao, Chenjiang You, Brandon Le, Zhizhong Gong, Beixin Mo, Yiji Xia and Xuemei Chen*. (2019). NAD+-capped RNAs are widespread in the Arabidopsis transcriptome and can probably be translated. PNAS 116, 12094-12102
Zhenxia Su, Lihua Zhao, Yuanyuan Zhao, Shaofang Li, So Youn Won, Hanyang Cai, Lulu Wang, Zhenfang Li, Yuan Qin*, and Xuemei Chen*. (2017). The THO complex non-cell autonomously represses female germline specification through the TAS3-ARF3 module. Current Biology 27, 1597–1609.
Yu Yu, Lijuan Ji, Brandon Le, Jixian Zhai, Jiayi Chen, Elizabeth Luscher, Lei Gao, Chunyan Liu, Xiaofeng Cao, Beixin Mo, Jinbiao Ma, Blake C. Meyers, and Xuemei Chen*. (2017). ARGONAUTE10 promotes the degradation of miR165/6 through the SDN1 and SDN2 exonucleases in Arabidopsis. PLoS Biology 15(2): e2001272.
Shengben Li, Lin Liu, Xiaohong Zhuang, Yu Yu, Xigang Liu, Xia Cui, Lijuan Ji, Zhiqiang Pan, Xiaofeng Cao, Beixin Mo, Fuchun Zhang, Natasha Raikhel, Liwen Jiang, and Xuemei Chen*. (2013). microRNAs inhibit the translation of target mRNAs on the endoplasmic reticulum in Arabidopsis. Cell 153, 562-574.
Yuanyuan Zhao, Yu Yu, Jixian Zhai, Vanitharani Ramachandran, Thanh Theresa Dinh, Blake C. Meyers, Beixin Mo*, and Xuemei Chen*. (2012). The Arabidopsis nucleotidyl transferase HESO1 uridylates unmethylated small RNAs to trigger their degradation. Current Biology 22, 689-694.
Vanitharani Ramachandran and Xuemei Chen*. (2008). Degradation of microRNAs by a family of exoribonucleases in Arabidopsis. Science 321, 1490-1492.
Junjie Li, Zhiyong Yang, Bin Yu, Jun Liu, and Xuemei Chen*. (2005). Methylation protects miRNAs and siRNAs from a 3’ end uridylation activity in Arabidopsis. Current Biology 15, 1501-1507.
Bin Yu, Zhiyong Yang, Junjie Li, Svetlana Minakhina, Maocheng Yang, Richard W. Padgett, Ruth Steward, and Xuemei Chen*. (2005). Methylation as a crucial step in plant microRNA biogenesis. Science 307, 932-935.
Xuemei Chen*. (2004). A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development. Science 303, 2022-2025.
