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个人简历
教育经历
2008 - 2011 , 访问研究生 , 动物遗传 , National Cancer Institute-Frederick, MD
2006 - 2011 , 理学博士 , 动物学 , 四川大学生命科学学院
2002 - 2006 , 理学学士 , 生物科学 , 四川大学生命科学学院
2006 - 2011 , 理学博士 , 动物学 , 四川大学生命科学学院
2002 - 2006 , 理学学士 , 生物科学 , 四川大学生命科学学院
工作经历
2013.7 －至今，副研究员，北京大学生命科学学院
2011.6 －2013.6，博士后，北京大学生命科学学院
2011.6 －2013.6，博士后，北京大学生命科学学院
科研领域描述
Felid exhibit tremendous intra- and inter-species coat color/pattern variations, yet the genetic basis of these variations remains largely unknown. Our research takes the advantage of the latest felid genome assembly (i.e. domestic cat, tiger) and the cut-edge sequencing technique to reveal the genetic mechanism underlying the coat color determination of felid.
代表性论文
1. Xu X, Sun X, Hu XS, Zhuang Y, Liu YC, Meng H, Miao L, Yu H, Luo SJ, Whole Genome Sequencing Identifies a Missense Mutation in HES7 Associated with Short Tails in Asian Domestic Cats. Sci Rep, 2016, 6:31583.
2. Zhang MQ, Xu X*, Luo SJ* , The genetics of brown coat color and white spotting in domestic yaks (Bos grunniens) , Anim Genet , 2014 , 45: 652-659,(* co-corresponding author)
3. Cho YS, Hu L, …, Xu X, …, Wang J, Bhak J , The tiger genome and comparative analysis with lion and snow leopard genomes , Nat Commun , 2013 , 4: 2433
4. Xu X, Dong GX, Hu XS, Miao L, Zhang XL, Zhang DL, Yang HD, Zhang TY, Zou ZT, Zhang TT, Zhuang Y, Bhak J, Cho YS, Dai WT, Jiang TJ, Xie C, Li R, Luo SJ , The genetic basis of white tigers , Curr Biol , 2013 , 23:1031-1035,(Cover Story)
5. Kaelin CB*, Xu X*, Hong LZ, David VA, McGowan KA, Schmidt-Kuntzel A, Roelke ME, Pontius J, Cooper GM, Manuel H, Marker L, Harper CK, van Dyk A, Yue B, Mullikin JC, Warren WC, Eizirik E, O’Brien SJ, Barsh GS, Menotti-Raymond M , Specifying and sustaining pigmentation pattern in domestic and wild cats , Science , 2012 , 337: 1536-1541,(* equal contribution)
2. Zhang MQ, Xu X*, Luo SJ* , The genetics of brown coat color and white spotting in domestic yaks (Bos grunniens) , Anim Genet , 2014 , 45: 652-659,(* co-corresponding author)
3. Cho YS, Hu L, …, Xu X, …, Wang J, Bhak J , The tiger genome and comparative analysis with lion and snow leopard genomes , Nat Commun , 2013 , 4: 2433
4. Xu X, Dong GX, Hu XS, Miao L, Zhang XL, Zhang DL, Yang HD, Zhang TY, Zou ZT, Zhang TT, Zhuang Y, Bhak J, Cho YS, Dai WT, Jiang TJ, Xie C, Li R, Luo SJ , The genetic basis of white tigers , Curr Biol , 2013 , 23:1031-1035,(Cover Story)
5. Kaelin CB*, Xu X*, Hong LZ, David VA, McGowan KA, Schmidt-Kuntzel A, Roelke ME, Pontius J, Cooper GM, Manuel H, Marker L, Harper CK, van Dyk A, Yue B, Mullikin JC, Warren WC, Eizirik E, O’Brien SJ, Barsh GS, Menotti-Raymond M , Specifying and sustaining pigmentation pattern in domestic and wild cats , Science , 2012 , 337: 1536-1541,(* equal contribution)
实验室简介
基因组多样性和演化实验室成立于2009年，以猫科动物基因组学和保护生物学研究为核心，具备分子生物学和生物信息学干湿实验综合实力。实验室建有生物样品库及数据库管理系统、古DNA超净平台、基因组数据处理计算服务器等硬件设施；在高通量数据分析、动物基因组组装与注释、群体基因学、基因与性状关联性分析、连锁遗传定位等有丰富的数据分析经验；且能有效开展分子生物学、生化和细胞水平的功能实验。
