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个人简历
教育经历
2005-2011 博士，美国威斯康辛大学麦迪逊分校
2003-2005 硕士，美国波士顿大学
1999-2003 学士，台湾成功大学
2003-2005 硕士，美国波士顿大学
1999-2003 学士，台湾成功大学
工作经历
2017-至今 研究员， 北京大学生命科学学院
2017-至今 研究员， 北大清华生命科学联合中心
2011-2017 博士后，美国麻省理工学院怀特黑德生物医学研究所
2017-至今 研究员， 北大清华生命科学联合中心
2011-2017 博士后，美国麻省理工学院怀特黑德生物医学研究所
荣誉奖励
Charles H. Hood基金会博士后奖学金，2015
美国心脏学会博士研究生奖学金，2009
美国心脏学会博士研究生奖学金，2009
科研领域描述
李湘盈课题组专注于探索干细胞「自我更新及分化」的分子机理，特别是细胞内信号通路如何与外在环境因素交互作用并影响干细胞的命运。干细胞「自我更新」和「分化」之间的平衡对于器官正常发育及组织再生起到关键性的作用。为了更深入的了解调控干细胞自我更新与复制的机制，课题组以血液干细胞特别是红系发育为模型。红细胞是人体内数量最多的细胞，正常人体每秒钟需制造约三百万的红细胞, 以维持体内正常供氧的需求。 李湘盈研究员过去的研究中，通过运用人类基因组学，化学药物筛选以及单细胞RNA测序技术，发现多种影响红系祖细胞BFU-E与其他血液干细胞自我复制的新机制, 研究成果发表於Nature, Molecular Cell, PNAS, Blood等期刊。
课题组以血液系统为基础，结合人类遗传学，细胞生物学及生物化学，系统性地分析调控干细胞特别是血液干细胞复制与分化的机制，从而发现新的调控因子，并进一步理解血液疾病的致病机理以及开发新的治疗方法。
课题组以血液系统为基础，结合人类遗传学，细胞生物学及生物化学，系统性地分析调控干细胞特别是血液干细胞复制与分化的机制，从而发现新的调控因子，并进一步理解血液疾病的致病机理以及开发新的治疗方法。
代表性论文
(*Equal contribution)
1. Hu, Q.*, Liu, Y.*, Yue, Q., Zhou, S., Jin, X., Lin, F., Huang, X.J., Zhuang, J.#, Lu, J.#, Gao, X.# and Lee, H.Y.# (2024) Lenalidomide-induced pure red cell aplasia is associated with elevated expression of MHC-I molecules on erythrocytes. Nature Communications. https://doi.org/10.1038/s41467-024-54571-w
2. Liu, Y.*, Nie, X.*, Yao, X.*, Shou, H., Yang, Y., Ge, Y., Tong, X.#, Lee, H.Y.# and Gao, X.# (2024) Developing an erythrocyte-MHC-I conjugate for cancer treatment. Cell Discovery. 10, 99. https://doi.org/10.1038/s41421-024-00713-9.
3. Li, D., Zhao, X.Y., Zhou, S., Hu, Q., Wu, F. and Lee H.Y. (2023) Multidimensional profiling reveals GATA1-modulated stage-specific chromatin states and functional associations during human erythropoiesis. Nucleic Acids Research. https://doi.org/10.1093/nar/gkad468
4. Li, D.*, Wu, F.*, Zhou, S., Huang, X.J. and Lee H.Y. (2023) Heterochromatin rewiring and domain disruption-mediated chromatin compaction during erythropoiesis. Nature Structural &. Molecular Biology. https://doi.org/10.1038/s41594-023-00939-3
5. Gao, X.*, Lee, H.Y.*, Li, W., Platt, R.J., Barrasa, M.I., Ma, Q., Elmes, R.R., Rosenfeld, M.G. and Lodish, H.F. (2017) Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation. Proceedings of the National Academy of Sciences USA. 114(38), 10107-10112.
6. Gao, X.*, Lee, H.Y.*, da Rocha, E.L., Zhang, C., Lu, Y.F., Li, D., Feng, Y., Ezike, J., Elmes, R.R., Barrasa, M.I., Cahan, P., Li, H., Daley, G.Q. and Lodish, H.F. (2016) TGF-β inhibitors stimulate red cell production by enhancing self-renewal of BFU-E erythroid progenitors. Blood. 128(23), 2637-2641.
7. Lee, H.Y.*, Gao, X.*, Barrasa, M.I., Li, H., Elmes, R.R., Peters, L.L. and Lodish, H.F. (2015) PPAR-α and glucocorticoid receptor synergize to promote erythroid progenitor self-renewal. Nature. 522, 474-7.
8. Lee, H.Y., Johnson, K.D., Boyer, M. E. and Bresnick, E. H. (2011) Relocalizing genetic loci into specific subnuclear neighborhoods. Journal of Biological Chemistry. 286, 18834-18844.
9. Fujiwara, T.*, Lee, H.Y.*, Sanalkumar, R.* and Bresnick, E. H. (2010) Building multifunctionality into a complex containing master regulators of hematopoiesis. Proceedings of the National Academy of Sciences USA. 107, 20429-34.
10. Lee, H.Y., Johnson, K. D., Fujiwara, T., Boyer, M. E., Kim, S.-I. and Bresnick, E. H. (2009) Controlling hematopoiesis through sumoylation-dependent regulation of a GATA factor. Molecular Cell. 36, 984-995.
1. Hu, Q.*, Liu, Y.*, Yue, Q., Zhou, S., Jin, X., Lin, F., Huang, X.J., Zhuang, J.#, Lu, J.#, Gao, X.# and Lee, H.Y.# (2024) Lenalidomide-induced pure red cell aplasia is associated with elevated expression of MHC-I molecules on erythrocytes. Nature Communications. https://doi.org/10.1038/s41467-024-54571-w
2. Liu, Y.*, Nie, X.*, Yao, X.*, Shou, H., Yang, Y., Ge, Y., Tong, X.#, Lee, H.Y.# and Gao, X.# (2024) Developing an erythrocyte-MHC-I conjugate for cancer treatment. Cell Discovery. 10, 99. https://doi.org/10.1038/s41421-024-00713-9.
3. Li, D., Zhao, X.Y., Zhou, S., Hu, Q., Wu, F. and Lee H.Y. (2023) Multidimensional profiling reveals GATA1-modulated stage-specific chromatin states and functional associations during human erythropoiesis. Nucleic Acids Research. https://doi.org/10.1093/nar/gkad468
4. Li, D.*, Wu, F.*, Zhou, S., Huang, X.J. and Lee H.Y. (2023) Heterochromatin rewiring and domain disruption-mediated chromatin compaction during erythropoiesis. Nature Structural &. Molecular Biology. https://doi.org/10.1038/s41594-023-00939-3
5. Gao, X.*, Lee, H.Y.*, Li, W., Platt, R.J., Barrasa, M.I., Ma, Q., Elmes, R.R., Rosenfeld, M.G. and Lodish, H.F. (2017) Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation. Proceedings of the National Academy of Sciences USA. 114(38), 10107-10112.
6. Gao, X.*, Lee, H.Y.*, da Rocha, E.L., Zhang, C., Lu, Y.F., Li, D., Feng, Y., Ezike, J., Elmes, R.R., Barrasa, M.I., Cahan, P., Li, H., Daley, G.Q. and Lodish, H.F. (2016) TGF-β inhibitors stimulate red cell production by enhancing self-renewal of BFU-E erythroid progenitors. Blood. 128(23), 2637-2641.
7. Lee, H.Y.*, Gao, X.*, Barrasa, M.I., Li, H., Elmes, R.R., Peters, L.L. and Lodish, H.F. (2015) PPAR-α and glucocorticoid receptor synergize to promote erythroid progenitor self-renewal. Nature. 522, 474-7.
8. Lee, H.Y., Johnson, K.D., Boyer, M. E. and Bresnick, E. H. (2011) Relocalizing genetic loci into specific subnuclear neighborhoods. Journal of Biological Chemistry. 286, 18834-18844.
9. Fujiwara, T.*, Lee, H.Y.*, Sanalkumar, R.* and Bresnick, E. H. (2010) Building multifunctionality into a complex containing master regulators of hematopoiesis. Proceedings of the National Academy of Sciences USA. 107, 20429-34.
10. Lee, H.Y., Johnson, K. D., Fujiwara, T., Boyer, M. E., Kim, S.-I. and Bresnick, E. H. (2009) Controlling hematopoiesis through sumoylation-dependent regulation of a GATA factor. Molecular Cell. 36, 984-995.
执教课程
Advanced Cell Biology
