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个人简历
教育经历
2001 - 2007，理学博士，生物信息，北京大学
1997 - 2001，理学学士，生物化学与分子生物学，山东大学
1997 - 2001，理学学士，生物化学与分子生物学，山东大学
工作经历
2007 - 2012，工程师，北京大学
2012 - 今，高级工程师，北京大学
2018 - 今，人类遗传资源中心 主任
2012 - 今，高级工程师，北京大学
2018 - 今，人类遗传资源中心 主任
科研领域描述
基因表达调控网络、生物大数据可视化、生命科学领域高性能计算
代表性论文
1. Bu D, Luo H, Huo P, Wang Z, Zhang S, He Z, Wu Y, Zhao L, Liu J, Guo J, Fang S, Cao W, Yi L, Zhao Y, Kong L. KOBAS-i: intelligent prioritization and exploratory visualization of biological functions for gene enrichment analysis. Nucleic Acids Res. 2021 Jun 4:gkab447. doi: 10.1093/nar/gkab447. PMID: 34086934.
2. Zhu Q, Shao Y, Wang Z, Chen X, Li C, Liang Z, Jia M, Guo Q, Zhao H, Kong L, Zhang L. DeepS: A web server for image optical sectioning and super resolution microscopy based on a deep learning framework. Bioinformatics. 2021 Mar 2:btab144. doi: 10.1093/bioinformatics/btab144. PMID: 33677518. （并列通信作者）
3. Wang M., Kong L. pblat: a multithread blat algorithm speeding up aligning sequences to genomes. BMC Bioinformatics. 2019 Jan 15;20(1):28. doi: 10.1186/s12859-019-2597-8.
4. Ai C., Kong L. CGPS: A machine learning-based approach integrating multiple gene set analysis tools for better prioritization of biologically relevant pathways. J Genet Genomics. 2018 Sep 13. pii: S1673-8527(18)30163-2. doi: 10.1016/j.jgg.2018.08.002.
5. Kong L, Cheng L, Fan LY, Zhao M, Qu H. IQdb: an intelligence quotient score-associated gene resource for human intelligence. Database (Oxford). 2013 Sep 11;2013:bat063. doi: 10.1093/database/bat063. PubMed PMID: 24030781; PubMed Central PMCID: PMC3770929.
6. Wang J, Kong L, Gao G, Luo J. A brief introduction to web-based genome browsers. Brief Bioinform. 2013 Mar;14(2):131-43. doi: 10.1093/bib/bbs029. Review. PubMed PMID: 22764121.
7. Kong L, Wang J, Zhao S, Gu X, Luo J, Gao G. ABrowse--a customizable next-generation genome browser framework. BMC Bioinformatics. 2012 Jan 5;13:2.doi: 10.1186/1471-2105-13-2. PubMed PMID: 22222089; PubMed Central PMCID:PMC3265404.
8. Xie C, Mao X, Huang J, Ding Y, Wu J, Dong S, Kong L, Gao G, Li CY, Wei L. KOBAS 2.0: a web server for annotation and identification of enriched pathways and diseases. Nucleic Acids Res. 2011 Jul;39(Web Server issue):W316-22. doi: 10.1093/nar/gkr483. PubMed PMID: 21715386; PubMed Central PMCID: PMC3125809.
9. Wang J, Kong L, Zhao S, Zhang H, Tang L, Li Z, Gu X, Luo J, Gao G. Rice-Map: a new-generation rice genome browser. BMC Genomics. 2011 Mar 30;12:165. doi:10.1186/1471-2164-12-165. PubMed PMID: 21450055; PubMed Central PMCID:PMC3072960.（并列第一作者）
10. Kong L, Zhang Y, Ye ZQ, Liu XQ, Zhao SQ, Wei L, Gao G. CPC: assess the protein-coding potential of transcripts using sequence features and support vector machine. Nucleic Acids Res. 2007 Jul;35(Web Server issue):W345-9. PubMed PMID: 17631615; PubMed Central PMCID: PMC1933232.
2. Zhu Q, Shao Y, Wang Z, Chen X, Li C, Liang Z, Jia M, Guo Q, Zhao H, Kong L, Zhang L. DeepS: A web server for image optical sectioning and super resolution microscopy based on a deep learning framework. Bioinformatics. 2021 Mar 2:btab144. doi: 10.1093/bioinformatics/btab144. PMID: 33677518. （并列通信作者）
3. Wang M., Kong L. pblat: a multithread blat algorithm speeding up aligning sequences to genomes. BMC Bioinformatics. 2019 Jan 15;20(1):28. doi: 10.1186/s12859-019-2597-8.
4. Ai C., Kong L. CGPS: A machine learning-based approach integrating multiple gene set analysis tools for better prioritization of biologically relevant pathways. J Genet Genomics. 2018 Sep 13. pii: S1673-8527(18)30163-2. doi: 10.1016/j.jgg.2018.08.002.
5. Kong L, Cheng L, Fan LY, Zhao M, Qu H. IQdb: an intelligence quotient score-associated gene resource for human intelligence. Database (Oxford). 2013 Sep 11;2013:bat063. doi: 10.1093/database/bat063. PubMed PMID: 24030781; PubMed Central PMCID: PMC3770929.
6. Wang J, Kong L, Gao G, Luo J. A brief introduction to web-based genome browsers. Brief Bioinform. 2013 Mar;14(2):131-43. doi: 10.1093/bib/bbs029. Review. PubMed PMID: 22764121.
7. Kong L, Wang J, Zhao S, Gu X, Luo J, Gao G. ABrowse--a customizable next-generation genome browser framework. BMC Bioinformatics. 2012 Jan 5;13:2.doi: 10.1186/1471-2105-13-2. PubMed PMID: 22222089; PubMed Central PMCID:PMC3265404.
8. Xie C, Mao X, Huang J, Ding Y, Wu J, Dong S, Kong L, Gao G, Li CY, Wei L. KOBAS 2.0: a web server for annotation and identification of enriched pathways and diseases. Nucleic Acids Res. 2011 Jul;39(Web Server issue):W316-22. doi: 10.1093/nar/gkr483. PubMed PMID: 21715386; PubMed Central PMCID: PMC3125809.
9. Wang J, Kong L, Zhao S, Zhang H, Tang L, Li Z, Gu X, Luo J, Gao G. Rice-Map: a new-generation rice genome browser. BMC Genomics. 2011 Mar 30;12:165. doi:10.1186/1471-2164-12-165. PubMed PMID: 21450055; PubMed Central PMCID:PMC3072960.（并列第一作者）
10. Kong L, Zhang Y, Ye ZQ, Liu XQ, Zhao SQ, Wei L, Gao G. CPC: assess the protein-coding potential of transcripts using sequence features and support vector machine. Nucleic Acids Res. 2007 Jul;35(Web Server issue):W345-9. PubMed PMID: 17631615; PubMed Central PMCID: PMC1933232.
实验室简介
主要的研究方向在于运用数学和大规模科学计算的方法去模拟、数值仿真、分析神经生物学中神经元网络的动力学特性，通过数学分析了解哺乳动物皮层的生物功能是如何在神经元网络各组分之间的相互作用中产生的。在神经生物学领域中最有意义的贡献是揭示了神经元网络动力学和网络结构之间的可能联系，而此联系已有神经生理学上的实验证据。并且通过模拟哺乳动物视皮层的大规模神经元网络，利用数学方法找到了一个可能的分岔结构确定了一个视皮层动力学上的运行点，从而发现了哺乳动物视觉朝向选择性的一个新机制。回国之后，课题组已经 (1) 利用数据时空分解方法研究大规模神经元网络的动力学性质并进行数据驱动式降维; (2) 应用数学降维方法，开拓分析光学成像数据的技术，发展预测神经元功能网络和功能连通性(functional connectivity)的算法，(3) 开展同时具有高空间分辨率和高时间分辨率的光学成像技术，研发线虫行为及其神经环路同步成像的光学成像系统。
