北京大学 | ENGLISH
讲座信息
Genetic dissection of p75 neurotrophin receptor signaling in mouse models of Alzheimer’s Disease
发布时间:2018-11-13      点击量:1268
主讲人:Prof. Carlos Ibanez
讲座地点:RM 1113, Wang Kezhen Building
讲座日期:2018-11-27
讲座时间:13:00 — 15:00
联系人:Prof. Yi Rao
 

IDG/麦戈文脑科学研究所讲座

Title:Genetic dissection of p75 neurotrophin receptor signaling in mouse models of Alzheimer’s Disease

Time: 13:00-15:00, 11/27/2018
Location: RM 1113,  Wang Kezhen Building
Speaker: Prof. Carlos Ibanez, Department of Physiology, Yong Loo Lin School of Medicine, NUS
Host: Prof. Yi Rao

Abstract: The p75 neurotrophin receptor (p75ntr) is a member of the Tumor Necrosis Factor Receptor (TNFR) Superfamily of “death receptors”. Neurotrophin binding to p75ntr can induce neuronal death, neurite dystrophy, synapse elimination and synaptic long term depression (LTD). It has therefore been regarded as a prominent contributor to neurodegenerative processes, such as those undergoing in Alzheimer’s Disease (AD). The role of p75ntr in AD is unclear, as it has been reported to contribute to both Aβ peptide clearance as well as Aβ-mediated neurodegeneration. This presentation will summarize the latest results of our team using mice carrying different alleles of p75ntr lacking distinct functions. Through this approach, we have unravelled a previously unknown, unexpected mechanism by which p75ntr regulates production of Aβ peptide, the main component of the amyloid plaques in AD.

欢迎各位老师同学积极参加!
[友情链接]
北大生科微信公众号 生声不息微信公众号
联系我们 | 地理位置
北京大学生命科学学院 版权所有 地址:北京市海淀区颐和园路5号金光生命科学大楼