生命科学学院2018年度春季学期学术系列讲座之三
题目：PIN-ning down the function of D6PK protein kinases in auxin transport regulation
讲座人：Prof. Dr. Claus Schwechheimer
Chair for Plant Systems Biology
Technical University of Munich
Freising, Germany
时间：2018年3月30日（星期五），13:00-14:30
地点：生命科学学院邓祐才报告厅
主持人：瞿礼嘉教授
摘要：
The biosynthesis and proper distribution of the phytohormone auxin within the plant influences almost every aspect of plant growth and development. To the largest extent, differences in the morphology between plants are the results of differential auxin distribution and auxin actions at the level of individual plants cells. Whereas auxin transport from cell to cell and within a plant had for a long time been inferred solely based on the polar distribution of PIN auxin exporters, we have recently shown that PINs require activation by protein kinases, such as the D6 PROTEIN KINASE, to become active auxin transporters. I will describe the biochemistry of D6PK and mechanisms that are required for targeting D6PK to the plasma membrane and the PINs. I will also present data that challenge the current view of how PIN polarity is controlled by phosphorylation. Finally, I will highlight some other regulatory functions of D6PK that are independent of PIN-dependent auxin transport control.
This work is funded through grants from the Deutsche Forschungsgemeinschaft
参考文献：
Barbosa, I.C. et al. (2018) Activation and polarity control of PIN-FORMED auxin transporters by phosphorylation. Trends Plant Sci In press.
Haga, K. et al. (2018) Roles of AGCVIII Kinases in the Hypocotyl Phototropism of Arabidopsis Seedlings. Plant Cell Physiol doi: 10.1093/pcp/pcy048.
Weller, B. et al. (2017) Dynamic PIN-FORMED auxin efflux carrier phosphorylation at the plasma membrane controls auxin efflux-dependent growth. Proc Natl Acad Sci U S A 114 (5), E887-E896.
Barbosa, I.C. et al. (2016) Phospholipid composition and a polybasic motif determine D6 PROTEIN KINASE polar association with the plasma membrane and tropic responses. Development 143 (24), 4687-4700.
Stanislas, T. et al. (2015) Arabidopsis D6PK is a lipid domain-dependent mediator of root epidermal planar polarity. Nat Plants 1, 15162.
Zourelidou, M. et al. (2014) Auxin efflux by PIN-FORMED proteins is activated by two different protein kinases, D6 PROTEIN KINASE and PINOID. Elife 3.
Barbosa, I.C. et al. (2014) D6 PROTEIN KINASE activates auxin transport-dependent growth and PIN-FORMED phosphorylation at the plasma membrane. Dev Cell 29 (6), 674-85.
Barbosa, I.C. and Schwechheimer, C. (2014) Dynamic control of auxin transport-dependent growth by AGCVIII protein kinases. Curr Opin Plant Biol 22, 108-15.
Willige, B.C. et al. (2013) D6PK AGCVIII kinases are required for auxin transport and phototropic hypocotyl bending in Arabidopsis. Plant Cell 25 (5), 1674-88.
Zourelidou, M. et al. (2009) The polarly localized D6 PROTEIN KINASE is required for efficient auxin transport in Arabidopsis thaliana. Development 136 (4), 627-36.
欢迎各位老师同学积极参加！